Animal studies have suggested that the peptide derivative Tesamorelin may help reduce weight, cardiovascular illness, and dementia. Scientists are currently investigating it thoroughly for its many possible health properties. Tesamorelin peptide is only available to those with valid medical or study professional licensure.
What follows is a comprehensive summary of Tesamorelin for anyone curious about learning more about this intriguing compound. Read on to find out what it can do, what studies have been done on it, if it has any effects, and where you can get some online from Core Peptides.
Tesamorelin Peptide: What is it?
Tesamorelin peptide is a 44-amino-acid fragment of GHRP-2 fused to a trans-3-hexenoic acid group. Scientific studies have purported that this peptide may reduce the symptoms of moderate cognitive impairment (MCI), a condition that often precedes dementia, and boost peripheral nerve regrowth. Research indicates that incorporating trans-3-hexanoic acid into Tesamorelin renders it more stable in rodent plasma, extending its half-life.
Tesamorelin Peptide: Mechanism Of Action
According to research, Tesamorelin is a synthesized peptide that seems to stimulate lipolysis by stimulating the pituitary gland. Lipolysis is the destruction of fats and lipids, leading to weight reduction. Both lipase and lipids are forms of fat that the body stores for later use as an energy source. However, extremely high levels of either are associated with an increased danger of developing numerous diseases, including heart disease.
As per study findings [i], Tesamorelin is believed to be effective because it appears to reduce abdominal obesity in the midsection. Research suggests that after 26 weeks, rodents given Tesamorelin for weight reduction seemed to have lost 15% of their body weight.
Tesamorelin has been hypothesized in independent research conducted in 2014 to reduce obesity around the liver by 18%. Mice used in the studies were given Tesamorelin daily.
Tesamorelin Peptide Properties
The possible properties of Tesamorelin have piqued the interest of scientists who want to learn more about this peptide and its potential applications. This article will examine Tesamorelin’s theorized properties, as scientific studies suggested.
Tesamorelin Peptide and Weight
Clinical studies indicate that Tesamorelin may have potent weight reduction properties, including decreased belly obesity. Many rodents were given Tesamorelin to aid in their weight loss exertions. Researchers are curious about this peptide because of its possible role in weight reduction.
Tesamorelin Peptide and Strength
Studies have theorized that Tesamorelin may increase muscular body composition and aid tissue development and healing by elevating the body’s growth hormone.
Tesamorelin Peptide and Chronic Peripheral Nerve Injury
Some medical treatments, injuries, and diabetes are all potential causes of peripheral nerve loss. Debilitating issues with movement and cognitive function are common results of this disease. Damage to the peripheral nervous system has few effective treatments because nerve cells are difficult to repair.
Data suggests that Tesamorelin’s presentation, based on growth hormone manipulation, may aid in the context of peripheral nerve damage and speed up recovery.
Tesamorelin Peptide and HIV
Some recent studies have linked HAART to GH insufficiency and other biochemical and hormonal problems. Why? Because HIV infection alters the pituitary gland, leading to GH insufficiency in 30% of rodents. According to extensive research, this deficit seems to be aided by Tesamorelin’s presentation.
Tesamorelin Peptide and HIV-Associated Lipodystrophy
Lipodystrophy, a disease in which the body cannot generate and sustain healthy fatty tissue, has been linked to HIV in studies [ii]. Contrarily, excess fat deposits itself in the midsection and elsewhere. There is no known physiological reason for lipodystrophy, but Tesamorelin peptide is being studied as a potential adjuvant.
Tesamorelin Peptide and the Heart
Studies have shown that aberrant fat accumulation raises the chance of cardiovascular disease (CVD) in test subjects living with HIV. Health experts agree that reducing the risk of cardiovascular disease is crucial for HIV-positive rodents. In addition, it would make them live longer.
Tesamorelin has been indicated to lower triglyceride, non-HDL-C, and cholesterol levels in HIV-infected rodents.
Tesamorelin Peptide and Dementia
New data suggests that Tesamorelin may help rodents with moderate cognitive disabilities remember more. The tesamorelin peptide has been hypothesized to cease or delay the progression of dementia by improving memory in the early phases of the disease.
Research conducted at the University of Washington School of Medicine suggests that reducing myo-insoitol (MI) levels and raising gamma-aminobutyric acid (GABA) may affect dementia.
References
[i] Stanley, Takara L., Meghan N. Feldpausch, Jinhee Oh, Karen L. Branch, Hang Lee, Martin Torriani, and Steven K. Grinspoon. “Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation.” JAMA 312, no. 4 (July 23, 2014): 380. doi:10.1001/jama.2014.8334.
[ii] Falutz, Julian, Soraya Allas, Jean-Claude Mamputu, Diane Potvin, Donald Kotler, Michael Somero, Daniel Berger, et al. “Long-Term Safety and Effects of Tesamorelin, a Growth Hormone-Releasing Factor Analogue, in HIV Patients with Abdominal Fat Accumulation.” AIDS 22, no. 14 (September 2008): 1719–1728. doi:10.1097/qad.0b013e32830a5058
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