{"id":125986,"date":"2021-03-24T11:06:12","date_gmt":"2021-03-24T15:06:12","guid":{"rendered":"https:\/\/antiguanewsroom.com\/?p=125986"},"modified":"2021-03-24T11:06:12","modified_gmt":"2021-03-24T15:06:12","slug":"india-claims-it-has-spotted-a-double-mutant-covid-variant-that-spreads-easier-and-may-escape-vaccines","status":"publish","type":"post","link":"https:\/\/antiguanewsroom.com\/india-claims-it-has-spotted-a-double-mutant-covid-variant-that-spreads-easier-and-may-escape-vaccines\/","title":{"rendered":"India claims it has spotted a \u2018double mutant\u2019 COVID variant that spreads easier and may escape vaccines"},"content":{"rendered":"
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India today claimed it has discovered a double mutant coronavirus variant that spreads more easily and may make vaccines less potent.<\/p>

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It said the the strain, which has two key alterations on its spike protein, was detected in samples in the western state of Maharashtra.<\/p>\n

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Indian scientists believe the variant is a hybrid of two different Covid strains, which happens when two viruses merge together inside an infected person.<\/p>

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In a press release, the health ministry said the variant\u2019s mutations signal \u2018immune escape and increased infectivity\u2019.<\/p>

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But it added the strain had not been detected in high enough numbers to be behind India\u2019s latest wave of infections.<\/p>\n

The unnamed variant has two main mutations that concern scientists \u2013 E484Q and L452R, which are thought to play a role in transmissibility and antibody escape.<\/p>

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However, British scientists told MailOnline today there was \u2018no evidence\u2019 to suggest the virus is a \u2018recombination variant\u2019, when two strains merge.<\/p>\n

Dr Simon Clarke, a molecular biologist at Reading University, said it was more likely to be a variant that randomly spawned with those two mutations on its spike.<\/p>

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He added: \u2018We shouldn\u2019t try to make this out to be something it\u2019s not, because it\u2019s most likely the same thing we\u2019ve seen in other variants, like the one in Brazil and South Africa \u2013 which all have multiple mutations on their spike protein. I\u2019ve not yet seen any evidence to suggest it is a recombinant.\u2019<\/p>

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Only one hybrid version of coronavirus has been spotted so far. It was found in the US and was a mix between the Kent variant and a strain found in California.<\/p>\n

Dr Clarke criticised the Indian health ministry for claiming the variant is more infectious and may be immune resistant, describing the claim as \u2018a bit bold\u2019.<\/p>\n

Dr Clarke added: \u2018It\u2019s entirely possible that it will turn out this variant does have some immune resistance, but the claim is definitely rather bold.\u2019<\/p>\n

He explained the E484Q mutation is a less radical change than the E484K found on the Brazilian and South African variants.<\/p>\n

For this reason, Dr Clarke suspects E484Q will not have the same effect as E484K, which makes immunity from vaccines and previous infection less strong.<\/p>\n

Dr Clarke said: \u2018And as for the L452R mutation, we\u2019re still waiting for a proper definition on what it does.\u2019<\/p>\n

The new Indian variant was spotted through genomics sequencing, when scientists analyse the genes of individual samples of positive Covid tests.<\/p>\n

The government samples collected from Maharashtra showed \u2018an increase in the fraction of samples with the E484Q and L452R mutations\u2019 compared with December last year.<\/p>\n

It\u2019s not clear how many cases of the variant were detected, but the government denied that the rise in case numbers was linked to the strain.<\/p>\n

In a statement, it said: \u2018Though VOCs [variants of concern] and a new double mutant variant have been found in India, these have not been detected in numbers sufficient to either establish a direct relationship or explain the rapid increase in cases in some states.\u2019<\/p>\n

In total, scientists from the Indian SARS-CoV-2 Consortium on Genomics (INSACOG) looked at 10,787 samples from 18 states.<\/p>\n

A total of 736 were positive for the UK variant, 34 for the South African variant and one for the Brazilian P.1 variant.<\/p>\n

Only one hybrid Covid variant has been spotted so far. It was formed from the Kent Covid variant \u2013 known scientifically as B.1.1.7 \u2013 and a Californian variant called B.1.429.<\/p>\n

Scientists in the US claim they merged in a \u2018recombination event\u2019, the New Scientist reports. This happens when two different versions of the virus infect the same cell and then swap genes while they are reproducing, giving rise to a new variant.<\/p>\n

Researchers have warned in the past that these events are possible but said they are \u2018unlikely\u2019 because they require very specific conditions and the coincidence of mostly uncontrollable events. They are more likely to happen during huge outbreaks.<\/p>\n

It is believed to have happened in this instance because a number of mutations matching those on the Kent and California variants all appeared in the same place at once. There are no details of the patient and it is unclear whether the combination happened in them, or whether they caught the variant from someone else.<\/p>\n

While experts have said there is no need to panic about new variants, one admitted recombination was \u2018dangerous\u2019 because it could change the virus so suddenly.<\/p>\n

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India today claimed it has discovered a double mutant coronavirus variant that spreads more easily and may make vaccines less potent. It said the the strain, which has two key alterations on its spike protein, was detected in samples in the western state of Maharashtra. 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